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Pharmacotherapeutic group: Anti-inflammatory preparations, non-steroids for topical use. ATC code: M02AA15.
Pharmacology: Pharmacodynamics: Diclofenac sodium is a non-steroidal anti-inflammatory drug (NSAID) which has also analgesic properties. The inhibition of prostaglandin synthesis is considered to be an essential part of its mode of action.
Pharmacokinetics: The achieved systemic concentrations of diclofenac are about 50 times lower than those achieved following oral administration of equivalent amounts of diclofenac. Systemic plasma levels are not supposed to contribute to the efficacy of Diclofenac gel. Diclofenac is extensively bound to plasma proteins (about 99 %). Diclofenac and its metabolites are excreted mainly in the urine.
